How about a low grav map,. Or a space map were you have a certian time to stablize the place before the cold vacum of space calls. If you Fail ? ? get to the life boats this can be were the zero G comes into effect, as you try to get to life boats. Certian rooms/ passages / sections ?could have this effect. This gives you the option of 2 ways to play the map. Have a time limit to the first objective ?(stablize the ship} Then if that fails go to the escape part.But if you have to get to the life boats make this the hardest part with more monsters/guards/soldiers/turrets. This will be so you do not take the infection/plague back with you.Again you could have a time limt to escape, after a set time and they have not escaped go to cut scene of a numpty zombie/soldier fiddling with the controls and the brown stuff hitting the fan ROFL
That's another good one EL, but again it's been done. There are already some Egypt themed maps with traps and so forth. I think I might roll with Dark's idea, because it actually runs parallel to an idea I was kicking around a few weeks ago after watching something on sci fi.